PAPP-A and FREE B-HCG
Pregnancy-associated Plasma Protein A (PAPP-A) and Free Beta-HCG are two biochemical markers for the early detection of aneuploidy (foetuses with an abnormal number of chromosomes) pregnancies.
Low level of PAPP-A may be commonly seen in prenatal screening for Down syndrome. Low levels may alternatively predict issues with the placenta, resulting in adverse complications.
PAPP-A is the largest of the pregnancy-associated proteins produced by both the embryo and the placenta during pregnancy.
Free Beta-HCG is a glycoprotein hormone normally produced by placenta during pregnancy. The hormone is present in blood and urine around 7 to 13 days following implantation of the fertilized ovum.
Increased values of Free Beta HCG in combination with the maternal age may indicate Down’s syndrome.
A double marker combination test of PAPP-A and Free Beta-HCG helps to identify, in weeks 11 to 14, 90% of pregnancies at risk for Down’s syndrome and 94% of all major chromosomal defects.
Clinipath are now performing the PAPP-A and Free Beta-HCG on site, the result being issued on the same day late in the afternoon.