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Clinipath Services Limited

Address: 217/3, Marina Street,
Pieta, PTA 9041,
Phone: 00356 21 221 355
Mobile: 00356 99 852 404
Fax: 00356 21 233 160

Contact persons:

Dr Stefan Laspina MD, FF Path, FRCPath
Mob: 99296046

Alex Gingell
Laboratory Director
Mob: 99430612

Prof A. Cilia Vincenti MD, FRCPath
Mob: 79441707

Clinic Hours:

Monday to Friday
8a.m. to 6p.m.

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18-07-2019 | RISK-PREGNANCY MARKERS perfomed at LAB



Pregnancy-associated Plasma Protein A (PAPP-A) and Free Beta-HCG are two biochemical markers for the early detection of aneuploidy (foetuses with an abnormal number of chromosomes) pregnancies.

 Low level of PAPP-A may be commonly seen in prenatal screening for Down syndrome. Low levels may alternatively predict issues with the placenta, resulting in adverse complications.

 PAPP-A is the largest of the pregnancy-associated proteins produced by both the embryo and the placenta during pregnancy.


Free Beta-HCG is a glycoprotein hormone normally produced by placenta during pregnancy. The hormone is present in blood and urine around 7 to 13 days following implantation of the fertilized ovum.

 Increased values of Free Beta HCG in combination with the maternal age may indicate Down’s syndrome.

 A double marker combination test of PAPP-A and Free Beta-HCG helps to identify, in weeks 11 to 14, 90% of pregnancies at risk for Down’s syndrome and 94% of all major chromosomal defects.


Clinipath are now performing the PAPP-A and Free Beta-HCG on site, the result being issued on the same day late in the afternoon.

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